Cerebral perfusion response to hyperoxia

Bulte, Daniel P., Chiarelli, Peter A., Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 and Jezzard, Peter 2007. Cerebral perfusion response to hyperoxia. Journal of Cerebral Blood Flow and Metabolism 27 (1) , pp. 69-75. 10.1038/sj.jcbfm.9600319

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Abstract

Graded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. Although the effects of hypoxia on blood flow have been extensively studied, the hyperoxic regime between normoxia and 100% inspired oxygen has been only intermittently studied. Subjects were studied at four levels of hyperoxia induced during a single session while perfusion was measured using arterial spin labelling MRI. Reductions in regional perfusion of grey matter were found to occur even at moderate levels of hyperoxia; however, perfusion changes at all oxygen levels were relatively mild (less than 10%) supporting the viability of hyperoxia-induced contrast.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	arterial spin labelling, hyperoxia, MRI, perfusion
Publisher:	Nature Publishing Group
ISSN:	0271-678X
Last Modified:	20 Oct 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/32549

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