Ustyugov, A. A., Shelkovnikova, Tatyana, Kokhan, V. S., Khritankova, I. V., Peters, Owen Morgan, Buchman, Vladimir L., Bachurin, S. O. and Ninkina, Natalia 2012. Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo. Bulletin of Experimental Biology and Medicine 152 (6) , pp. 731-733. 10.1007/s10517-012-1618-7 |
Official URL: http://dx.doi.org/10.1007/s10517-012-1618-7
Abstract
Aggregation of proteins liable to assembling into fi brils with subsequent formation of amyloid incorporations is an important component in the pathogenesis of many neurodegenerative diseases. Dimebon, a Russian drug, reduces the content of detergent-insoluble fi brillar forms of synuclein, the main protein component of pathological incorporations in neurons of transgenic mouse strain used in the study.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
Uncontrolled Keywords: | dimebon; neurodegeneration; synucleins; transgenic animals |
Additional Information: | Translated from Byulleten” Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 674-677, December, 2011 |
Publisher: | Springer |
ISSN: | 0007-4888 |
Last Modified: | 07 Feb 2022 10:53 |
URI: | https://orca.cardiff.ac.uk/id/eprint/32556 |
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