Breast cancer stem cells: obstacles to therapy

Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Piggott, Luke and Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673 2013. Breast cancer stem cells: obstacles to therapy. Cancer Letters 338 (1) , pp. 57-62. 10.1016/j.canlet.2012.04.023

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Abstract

Only a fraction of the cells in a breast tumour are able to seed new tumour growth. These so-called breast cancer stem cells (bCSCs) are characterised by a number of discrete functional properties, some of which impact on therapeutic strategies aimed at eliminating these cells from tumours. Here we discuss how recent experimental evidence indicates that phenotypic plasticity is a central feature of tumour cell heterogeneity and drug resistance, traits that must be overcome in order to efficiently target bCSCs as a therapy for breast cancer. We propose that a better understanding of this fundamental property of breast cancer stem cells, over and above their identification in tumours, is a priority for improvement of patient survival.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Research Institutes & Centres > European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Cancer stem cells; Breast; EMT; Plasticity
Publisher:	Elsevier
ISSN:	0304-3835
Last Modified:	07 Aug 2024 22:29
URI:	https://orca.cardiff.ac.uk/id/eprint/32571

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