Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophrenia

Uhlhaas, Peter J., Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292, Singer, Wolf, Haenschell, Corinna, Lindner, Michael, Maurer, Konrad and Rodriguez, Eugenio 2006. Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophrenia. Journal of Neuroscience 26 (31) , pp. 8168-8175. 10.1523/JNEUROSCI.2002-06.2006

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Abstract

Recent theoretical and empirical research on schizophrenia converges on the notion that core aspects of the pathophysiology of the disorder may arise from a dysfunction in the coordination of distributed neural activity. Synchronization of neural responses in the β-band (15–30 Hz) and γ-band range (30–80 Hz) has been implicated as a possible neural substrate for dysfunctional coordination in schizophrenia. To test this hypothesis, we examined the electroencephalography (EEG) activity in 19 patients with a Diagnostic and Statistical Manual of Mental Disorder, edition IV criteria, diagnosis of schizophrenia and 19 healthy control subjects during a Gestalt perception task. EEG data were analyzed for phase synchrony and induced spectral power as an index of neural synchronization. Schizophrenia patients were impaired significantly in the detection of images that required the grouping of stimulus elements into coherent object representations. This deficit was accompanied by longer reaction times in schizophrenia patients. Deficits in Gestalt perception in schizophrenia patients were associated with reduced phase synchrony in the β-band (20 –30 Hz), whereas induced spectral power in the γ-band (40 –70 Hz) was mainly intact. Our findings suggest that schizophrenia patients are impaired in the long-range synchronization of neural responses, which may reflect a core deficit in the coordination of neural activity and underlie the specific cognitive dysfunctions associated with the disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	schizophrenia; long-range coordination; synchronization; Gestalt perception; electroencephalography; β-oscillations
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 27/02/2014).
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	04 May 2023 15:08
URI:	https://orca.cardiff.ac.uk/id/eprint/32877

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