Distributed neural actions of anti-parkinsonian therapies as revealed by PET

Goerendt, I. K., Lawrence, Andrew David ORCID: https://orcid.org/0000-0001-6705-2110, Mehta, M. A., Stern, J. S., Odin, P. and Brooks, D. J. 2006. Distributed neural actions of anti-parkinsonian therapies as revealed by PET. Journal of Neural Transmission 113 (1) , pp. 75-86. 10.1007/s00702-005-0305-5

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Abstract

There is a limited understanding of how different anti-parkinsonian treatments act at the neuronal systems level. Using positron emission tomography we examined the effects of levodopa and deep brain stimulation of the subthalamic nucleus on patterns of regional cerebral blood flow in patients with Parkinson’s disease during a homogenous cognitive-behavioural state rather than during an unspecified resting state. We found that when medicated precuneus, frontal, parietal, cerebellar and midbrain areas were relatively more activated than when stimulated, whereas when stimulated the precentral gyrus, caudate and thalamus were relatively more activated than when medicated. Areas that were activated by both treatments included the temporal gyri, anterior thalamus, and midbrain. Regions of prefrontal cortex showed relatively greater activation in the “off treatment” conditions of both the medicated and stimulated groups. Our findings suggest that the two treatment methods may lead to symptomatic relief via both common and different sites of action.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Levodopa, deep brain stimulation, positron emission tomography
Publisher:	Springer Verlag
ISSN:	0300-9564
Last Modified:	20 Oct 2022 09:43
URI:	https://orca.cardiff.ac.uk/id/eprint/32924

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