Hale, Gemma and Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 2005. Impaired visuo-spatial recognition memory but normal object novelty detection and relative familiarity judgements in adult mice expressing the APPswe Alzheimer's disease mutation. Behavioral Neuroscience 119 (4) , pp. 884-891. 10.1037/0735-7044.119.4.884 |
Abstract
The present study examined the effects of a human APPswe mutation on object recognition memory in adult Tg2576 mice. The results showed that 14-month old Tg2576 mice were able to detect object novelty as well as control mice, even with delays of up to 24 hr. In addition, transgenic mice showed a normal recency effect and explored the most recently encountered object significantly less than an object encountered earlier in a trial. However, adult Tg2576 mice showed impairments in detecting a change in the relative positions of an array of familiar objects. The results suggest that the formation of representations involving a combination of object identity and spatial information are particularly sensitive to amyloid pathology in adult APPswe mutant mice. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Psychology |
Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Publisher: | American Psychological Association |
ISSN: | 0735-7044 |
Last Modified: | 17 Oct 2022 09:28 |
URI: | https://orca.cardiff.ac.uk/id/eprint/3293 |
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