Hippocampal lesions disrupt navigation based on the shape of the environment

McGregor, Anthony, Hayward, Andrew James, Pearce, John Martindale ORCID: https://orcid.org/0000-0001-6121-8650 and Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 2004. Hippocampal lesions disrupt navigation based on the shape of the environment. Behavioral Neuroscience 118 (5) , pp. 1011-1021. 10.1037/0735-7044.118.5.1011

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Abstract

Geometric information provided by the walls of an environment has a strong influence over hippocampal unit activity. This suggests that the hippocampus forms part of a cognitive mapping system that encodes geometric relationships between environmental cues and the animal's location. Here, the authors show for the first time that excitotoxic lesions of the hippocampus disrupt the ability of rats to navigate to a goal using shape information provided by a solid-walled arena and an array of identical landmarks. These results are consistent with cognitive mapping theories of hippocampal function and extend previous research by showing that hippocampal cell loss impairs navigation with respect to shape information provided by both physical barriers and an array of landmarks. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Psychological Association
ISSN:	0735-7044
Last Modified:	01 Dec 2022 11:03
URI:	https://orca.cardiff.ac.uk/id/eprint/3295

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