A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning

Humeau, Yann, Reisel, Daniel, Johnson, Alexander W., Borchardt, Thilo, Jensen, Vidar, Gebhardt, Christine, Bosch, Verena, Gass, Peter, Bannerman, David M., Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203, Hvalby, Øivind, Sprengel, Rolf and Luthi, Andreas 2007. A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. Journal of Neuroscience 27 (41) , pp. 10947-10956. 10.1523/JNEUROSCI.2603-07.2007

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Abstract

The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1−/− and GluR3−/−). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1−/− mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1−/− but not GluR3−/− mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Uncontrolled Keywords:	lateral amygdala; basal amygdala; fear conditioning; synaptic transmission; LTP; GluR1; GluR3
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 27/02/2014).
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	17 May 2023 02:54
URI:	https://orca.cardiff.ac.uk/id/eprint/33170

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