Humeau, Yann, Reisel, Daniel, Johnson, Alexander W., Borchardt, Thilo, Jensen, Vidar, Gebhardt, Christine, Bosch, Verena, Gass, Peter, Bannerman, David M., Good, Mark Andrew  ORCID: https://orcid.org/0000-0002-1824-1203, Hvalby, Øivind, Sprengel, Rolf and Luthi, Andreas
2007.
A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.
Journal of Neuroscience
27
(41)
, pp. 10947-10956.
10.1523/JNEUROSCI.2603-07.2007
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Abstract
The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1−/− and GluR3−/−). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1−/− mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1−/− but not GluR3−/− mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Psychology |
| Uncontrolled Keywords: | lateral amygdala; basal amygdala; fear conditioning; synaptic transmission; LTP; GluR1; GluR3 |
| Additional Information: | Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 27/02/2014). |
| Publisher: | Society for Neuroscience |
| ISSN: | 0270-6474 |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 17 May 2023 02:54 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/33170 |
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