Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology

Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308, Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773, Denby, Christine, Dix, Sophie, Mayes, Andrew R., Roberts, Neil and Yonelinas, Andrew P. 2005. Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology. Neuropsychologia 43 (12) , pp. 1810-1823. 10.1016/j.neuropsychologia.2005.01.019

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Abstract

Subject KN has a persistent anterograde amnesia as a result of brain injury following meningitis in 1993. MRI scans reveal a bilateral decrease in the volume of his hippocampal region (dentate gyrus, CA1–4, subicular cortices) of approximately 45% in both the right and left hemispheres, although the volume of his perirhinal cortex appears normal. Aside from some changes to his occipital lobe and bilateral shrinkage of the amygdala, the rest of his brain appears normal on recent quantitative MRI scans. A striking feature of his memory loss is his ability to perform at normal levels on some tests of recognition, despite his consistent deficit on tests of recall. Two tests designed specifically to distinguish performance of two putative divisions of recognition memory (the Remember/Know procedure and the use of receiver operating characteristics to distinguish familiarity and recollection), provide evidence for a selective sparing of the familiarity component of recognition. The dissociation within recognition memory supports dual-process models of recognition, and also supports proposals that anatomically linked regions within the medial temporal lobe make qualitatively different contributions to recognition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Amnesia; Recognition memory; Familiarity; Perirhinal cortex; Hippocampus
Publisher:	Elsevier
ISSN:	0028-3932
Last Modified:	07 Nov 2023 11:17
URI:	https://orca.cardiff.ac.uk/id/eprint/33212

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