Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?

Lawrence, Andrew David ORCID: https://orcid.org/0000-0001-6705-2110, Evans, Amdrew H. and Lees, Andrew J. 2003. Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry? The Lancet Neurology 2 (10) , pp. 595-604. 10.1016/S1474-4422(03)00529-5

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Abstract

Dopamine replacement therapy (DRT) is the most effective treatment for Parkinson's disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A few patients with PD, however, take increasing quantities of medication far beyond those required to treat their motor disabilities. These patients demand rapid drug escalation and continue to request more DRT despite the emergence of increasingly severe drug-induced motor complications and harmful behavioural consequences. In this article we detail the features of compulsive DRT-seeking and intake in PD, in relation to theories of compulsive drug use.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	1474-4422
Last Modified:	17 Oct 2022 09:29
URI:	https://orca.cardiff.ac.uk/id/eprint/3348

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