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Involvement of a metalloprotease in the shedding of human neutrophil FcγRIIIB

Middelhoven, P. J., Ager, Ann, Roos, D. and Verhoeven, A. J. 1997. Involvement of a metalloprotease in the shedding of human neutrophil FcγRIIIB. FEBS Letters 414 (1) , pp. 14-18. 10.1016/S0014-5793(97)00959-9

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FcγRIIIb is a glycosylphosphatidylinositol(GPI)-anchored, low-affinity IgG receptor, expressed exclusively on human neutrophils. Upon activation or apoptosis of neutrophils, FcγRIIIb is shed from the cell surface, but the enzyme(s) responsible for this process is (are) still unknown. Recently, metalloproteases have been suggested to mediate the shedding of cell surface proteins such as l-selectin and TNF-α. Using hydroxamic acid-based inhibitors of this class of proteases (BB-3103, Ro31-9790), we have observed a clear inhibitory effect on FcγRIIIb shedding after PMA stimulation of neutrophils or induction of apoptosis. These inhibitors did not affect PMA-induced degranulation or superoxide generation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: FcγRIIIb, proteolytic cleavage, hydroxamic acid-based inhibitor, metalloprotease, apoptosis
Publisher: Elsevier
ISSN: 0014-5793
Last Modified: 04 Jun 2017 04:08

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