ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults

Handley, Olivia Jane, Morrison, Catriona Morag, Miles, Christopher and Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X 2006. ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults. Neurobiology of Aging 27 (10) , pp. 1425-1430. 10.1016/j.neurobiolaging.2005.08.001

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Abstract

The study examined odour identification ability in healthy older adults at increased risk for developing Alzheimer's disease (AD). We recruited a sample (n = 24) of siblings related to probable AD cases and an age-matched control sample (n = 47). All participants were genotyped for the presence of the ApoE 4 allele. Performance on a simple olfactory task of odour identification was compared according to positive family history of AD and ApoE 4 status. The sibling group showed an odour identification deficit compared to the control group. Whilst there was no independent influence of ApoE 4 status on odour identification, there was a significant interaction between positive family history and ApoE 4 status. Sibling 4 carriers showed the greatest odour identification deficit and their performance was significantly poorer than both the sibling non-4 carrier and control 4 carrier groups. Odour identification deficits like those reported here are considered to be early cognitive markers of incipient AD. In this respect, these findings support the need to both monitor individuals at increased risk of the disease and introduce olfactory-mediated cognitive tasks into the diagnostic setting.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Aging; Alzheimer's disease; Cognitive impairment; ApoE; Olfaction
Publisher:	Elsevier
ISSN:	0197-4580
Last Modified:	01 Dec 2022 11:05
URI:	https://orca.cardiff.ac.uk/id/eprint/3371

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