Cavitation bubble-driven cell and particle behavior in an ultrasound standing wave

Kuznetsova, Larisa A., Khanna, Sanjay, Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623, Coakley, W. Terence and Doinikov, Alexander A. 2005. Cavitation bubble-driven cell and particle behavior in an ultrasound standing wave. Journal of the Acoustical Society of America 117 (1) , pp. 104-112. 10.1121/1.1835503

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Abstract

The behavior of human erythrocytes and 1-microm-diameter fluorescent latex beads in the presence of Optison contrast agent in a single half-wavelength (lambda/2) ultrasound standing wave (USSW) resonator has been studied. The particle movements were observed with an epi-fluorescent microscope and the velocity of the particles and cells was measured by particle image velocimetry (PIV). Acoustic emissions were monitored with a microphone and a spectrum analyzer. Optison contrast agent disintegrated immediately on exposure to ultrasound of 0.98-MPa acoustic pressure amplitude or higher in a chamber driven at its resonance frequency of 1.56 MHz. A discrete cloud of active microbubbles, detected at the pressure node plane, disappeared gradually and was completely lost within 15 s. The microscopy showed three-dimensional regions of circulation of both 1-microm tracer particles and erythrocytes in planes perpendicular to the pressure node plane. A numerical simulation showed that, for parameters that conform to the experimental conditions, a bubble of a subresonance size moves towards and translates about a pressure node plane. This result is in agreement with the experimental observation that the particle and cell circulation is induced by the presence and/or translational motion of microbubbles at the pressure node plane.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) T Technology > T Technology (General)
Uncontrolled Keywords:	bubbles ; acoustic resonance ; acoustic emission ; acoustic streaming ; biomedical ultrasonics ; bioacoustics ; particle velocity analysis ; cellular biophysics ; microphones ; spectral analysers
Publisher:	Acoustical Society of America
ISSN:	0001-4966
Last Modified:	07 Nov 2022 09:11
URI:	https://orca.cardiff.ac.uk/id/eprint/33807

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