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Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge

Ensari, A., Ager, Ann, Marsh, M. N., Morgan, S. and Moriarty, K. J. 1993. Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge. Clinical and experimental immunology 92 (2) , pp. 303-307. 10.1111/j.1365-2249.1993.tb03396.x

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Adhesive interactions between endothelium and circulating ceils, such as monocytes, neutrophils and lymphocytes, are crucial for localizing the inflammatory response. We investigated the inflammatory response of rectal mucosa to local gluten challenge as a dynamic model of antigen-induced tissue injury, during which the expression of adhesion molecules on leucocytes and endothelial cells could be sequentially observed. Expression of ELAM-I, lCAM-1 and VCAM-1 was monitored in 10 treated and eight untreated patients with gluten sensitivity (eoeliac disease), and in five disease controls for up to 4 h (short challenge), while a further seven treated coeliacs were monitored for up to 24 h (Iongchallenge) following reetal gluten challenge. In the former, Ihc expression of VCAM-1 and ELAM-I was significantly raised 4 h after gluten challenge compared with controls, VCAM-1 and ELAM-l expression was also increased in mucosac of treated patients. but to a lesser extent, VCAM-1 expression continued to increase for up to 24 h after gluten, while ELAM-l had begun to wane by 4 h, reaehing basal levels by 24 h, In eontrast, the expression of ICAM-1 did not change in any of the disease groups studied. These findings relate to significant increases in lymphocytes (CD3+ cells) after 8 h, and neutrophils (CD15+ cells) after 4h in the lamina propria. This approach has permitted novel studies of the infiammatory response to a defined antigen in sensitized (gluten-sensitive) human patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords: coeliac, rectal mucosa, adhesion molecules, lymphocyte neutrophil, antigen challenge, gluten
Publisher: Blackwell Publishing
ISSN: 0009-9104
Last Modified: 04 Jun 2017 04:11

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