Consequences of live poliovirus vaccine administration in chronic fatigue syndrome

Vedhara, K., Llewelyn, M. B., Fox, J. D., Jones, M., Jones, R., Clements, G. B., Wang, E. C. Y., Smith, Andrew Paul ORCID: https://orcid.org/0000-0001-8805-8028 and Borysiewicz, L. K. 1997. Consequences of live poliovirus vaccine administration in chronic fatigue syndrome. Journal of Neuroimmunology 75 (1-2) , pp. 183-195. 10.1016/S0165-5728(97)00032-5

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Abstract

The effect of live oral polio virus vaccination on chronic fatigue syndrome (CFS) patients was examined in a double-blind study. CFS patients were allocated randomly to placebo (N=7) or vaccine (N=7) conditions. All control subjects received the vaccine (9). Vaccine administration was not associated with clinical exacerbation of CFS. However, objective responses to the vaccine revealed differences between patients and controls: increased poliovirus isolation, earlier peak proliferative responses, lower T-cell subsets on certain days post vaccination and a trend for reduced γ-interferon in the CFS-vaccine group. Polio vaccination was not found to be clinically contraindicated in CFS patients, however, there was evidence of altered immune reactivity and virus clearance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QR Microbiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Chronic fatigue syndrome; Enterovirus; Virus shedding; Proliferative responses; Cytokines
Publisher:	Elsevier
ISSN:	0165-5728
Last Modified:	21 Oct 2022 08:49
URI:	https://orca.cardiff.ac.uk/id/eprint/34531

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