Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats?

Warburton, E. C., Morgan, A., Baird, Alison Lambie, Muir, Janice L. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 1999. Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats? Behavioral Neuroscience 113 (5) , p. 956. 10.1037//0735-7044.113.5.956

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Abstract

Rats that had been pretrained on 2 tests of allocentric memory (water maze and T maze) received bilateral cytotoxic lesions in the anterior thalamic nuclei (ATN) or transection of the fimbria-fornix (FF). After surgery, both groups of rats were impaired on both tasks, although the preoperative training resulted in a rapid initial reacquisition of the water maze task. Those rats with lesions largely restricted to the ATN were impaired at a level comparable to that produced by FF lesions. This finding is consistent with a close functional relationship between the hippocampus and the ATN, necessary for the acquisition and on-line processing of allocentric spatial information but not for the maintenance/retrieval of procedural information. The rats with more extensive thalamic lesions were more impaired in both tasks and did show a loss of procedural information.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Psychological Association
ISSN:	0735-7044
Last Modified:	21 Oct 2022 08:58
URI:	https://orca.cardiff.ac.uk/id/eprint/34927

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