Functionally dissociating aspects of event memory: The effects of combined perirhinal and postrhinal lesions on object and place memory in the rat

Bussey, T. J., Muir, Janice L. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 1999. Functionally dissociating aspects of event memory: The effects of combined perirhinal and postrhinal lesions on object and place memory in the rat. The Journal of Neuroscience 19 (1) , pp. 495-502.

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Abstract

Reciprocal interactions between the hippocampus and the perirhinal and parahippocampal cortices form core components of a proposed temporal lobe memory system. For this reason, the involvement of the hippocampus in event memory is thought to depend on its connections with these cortical areas. Contrary to these predictions, we found that NMDA-induced lesions of the putative rat homologs of these cortical areas (perirhinal plus postrhinal cortices) did not impair performance on two allocentric spatial tasks highly sensitive to hippocampal dysfunction. Remarkably, for one of the tasks there was evidence of a facilitation of performance. The same cortical lesions did, however, disrupt spontaneous object recognition and object discrimination reversal learning but spared initial acquisition of the discrimination. This pattern of results reveals important dissociations between different aspects of memory within the temporal lobe. Furthermore, it shows that the perirhinal–postrhinal cortex is not a necessary route for spatial information reaching the hippocampus and that object familiarity–novelty detection depends on different neural substrates than do other aspects of event memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	episodic memory; event memory; spatial memory; object recognition; perirhinal cortex; postrhinal cortex; temporal lobe; rat
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 27/02/2014).
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	07 May 2023 00:35
URI:	https://orca.cardiff.ac.uk/id/eprint/34932

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