Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region

Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203, Day, Mark and Muir, Janice L. 1999. Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region. European Journal of Neuroscience 11 (12) , pp. 4476-4480. 10.1046/j.1460-9568.1999.00920.x

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Abstract

The present study investigated the effects of naturally fluctuating endogenous levels of oestrogen on the induction and maintenance of long-term potentiation (LTP) and long-term depression (LTD) in the CA1 region of the hippocampus. Using an anaesthetized in vivo preparation, the results showed that the induction of LTP was augmented during the pro-oestrous stage of the oestrous cycle. In contrast to LTP, however, the induction of paired-pulse LTD was severely attenuated during pro-oestrous, but was clearly manifested by rats during met/dioestrous and oestrous stages of the cycle. These findings are discussed with reference to: (i) the modulatory effects of oestrogen on N-methyl-d-aspartate (NMDA) receptor function and γ-aminobutyric acid (GABA) neurotransmission in the hippocampus; and (ii) the functional implications that such cyclical changes in synaptic plasticity have for learning and memory processes supported by the hippocampus.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	hippocampus; LTD; LTP; oestrogen; paired pulse; synaptic plasticity
Publisher:	Wiley-Blackwell
ISSN:	0953-816X
Last Modified:	21 Oct 2022 09:00
URI:	https://orca.cardiff.ac.uk/id/eprint/35039

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