On the relationship between knowledge and memory for pictures: Evidence from the study of patients with semantic dementia and Alzheimer's disease

Graham, Kim Samantha ORCID: https://orcid.org/0000-0002-1512-7667, Becker, J. T. and Hodges, J. R. 1997. On the relationship between knowledge and memory for pictures: Evidence from the study of patients with semantic dementia and Alzheimer's disease. Journal of the International Neuropsychological Society 30 (6) , pp. 534-544.

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Abstract

Current views of long-term memory presume that both the hippocampal complex and the neocortex play interactive, but separate, roles in the storage of memories. While the neocortex is considered the eventual and permanent store for our memories, the encoding of recently experienced events is thought to be initially dependent upon the hippocampus and closely related structures. Neuropsychological studies have demonstrated that damage to the medial temporal lobe results in a retrograde amnesia extending back in time, with better preservation of older memories. The converse pattern has been shown in patients with semantic dementia, who have focal atrophy of the inferolateral temporal neocortex, but relative sparing of the hippocampal complex (Graham & Hodges, 1997). Here we demonstrate that such patients can show relatively preserved new learning on a forced-choice recognition memory test (based on real and chimeric animals), while patients in the early amnestic phase of Alzheimer's disease show severely impaired learning on the same test. This result provides support for the view that new learning is primarily dependent upon the hippocampus and related structures. (JINS, 1997, 3, 534–544.)

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Systems Immunity Research Institute (SIURI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Episodic memory; Hippocampus; Temporal neocortex; Long-term memory storage
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1355-6177/ (accessed 25/02/2014).
Publisher:	Cambridge University Press
ISSN:	1355-6177
Date of First Compliant Deposit:	30 March 2016
Last Modified:	05 May 2023 18:07
URI:	https://orca.cardiff.ac.uk/id/eprint/35110

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