Mice defective in fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production

Huang, Fang-Ping, Xu, Damo, Esfandiari, Eshan-O, Sands, William, Wei, Xiao-Qing ORCID: https://orcid.org/0000-0002-6274-8503 and Liew, Foo Y. 1998. Mice defective in fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. The Journal of Immunology 160 (9) , pp. 4143-4147.

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Abstract

MRL/MP-lpr/lpr (MRL/lpr) mice have a single mutation (lpr) of the fasapoptosis gene. The mutant mice developed significantly smaller lesions than the wild-type mice at the earlier stage of infection with the intracellular protozoan parasite Leishmania major. However, while all the wild-type mice achieved complete lesion resolution, the disease in the mutant mice progressed inexorably. The mutant mice had more IL-12 and nitrite/nitrate in the serum than wild-type mice following infection. Lymphoid cells from infected MRL/lpr mice produced more IFN-γ but less IL-4 and IL-5 than cells from MRL-+/+ mice. Peritoneal macrophages from the mutant mice also produced more IL-12 and NO after stimulation with LPS. Thus, Fas expression is essential for resistance against leishmaniasis, and Fas-mediated apoptosis may form an integral part of the Th1-mediated microbicidal function.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Last Modified:	21 Oct 2022 09:13
URI:	https://orca.cardiff.ac.uk/id/eprint/35657

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