Gut microbiota composition correlates with diet and health in the elderly

Claesson, Marcus J., Jeffery, Ian B., Conde, Susana, Power, Susan E., O'Connor, Eibhlís M., Cusack, Siobhán, Harris, Hugh M. B., Coakley, Mairead, Lakshminarayanan, Bhuvaneswari, O'Sullivan, Orla, Fitzgerald, Gerald F., Deane, Jennifer, O'Connor, Michael, Harnedy, Norma, O'Connor, Kieran, O'Mahony, Denis, van Sinderen, Douwe, Wallace, Martina, Brennan, Lorraine, Stanton, Catherine, Marchesi, Julian Roberto ORCID: https://orcid.org/0000-0002-7994-5239, Fitzgerald, Anthony P., Shanahan, Fergus, Hill, Colin, Ross, R. Paul and O'Toole, Paul W. 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488 (7410) , pp. 178-184. 10.1038/nature11319

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Abstract

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology
Uncontrolled Keywords:	Microbiology; Medical research; Health and medicine; Immunology
Publisher:	Nature Publishing Group
ISSN:	0028-0836
Last Modified:	21 Oct 2022 09:18
URI:	https://orca.cardiff.ac.uk/id/eprint/35899

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