Synthesis and antimicrobial activities of diphenyl (arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)methylphosphonates

Abdel-Megeed, Mohamed F., Badr, E., Azaam, Mohamed M. and El-Hiti, Gamal A. 2012. Synthesis and antimicrobial activities of diphenyl (arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)methylphosphonates. Phosphorus Sulfur and Silicon and the Related Elements 187 (12) , pp. 1462-1468. 10.1080/10426507.2012.690117

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Abstract

A series of novel diphenyl (arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)methylphosphonates have been synthesized in high yields. They were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Schccaromycies cerevisiae as a fungus. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed moderate antibacterial and antifungal activities at low concentrations (10–1000 μg/mL).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	α-aminophosphonates, antimicrobial, gram-negative and gram-positive bacteria, fungi, minimum inhibitory concentrations
Publisher:	Taylor & Francis
ISSN:	1042-6507
Last Modified:	19 Mar 2016 23:02
URI:	https://orca.cardiff.ac.uk/id/eprint/36103

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