Sexual differentiation of the brain: investigating the role of Sry using animal models

Kopsida, Eleni 2012. Sexual differentiation of the brain: investigating the role of Sry using animal models. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Recent findings have challenged the dogma that gonadal hormones are the sole factor mediating sexual differentiation of the mammalian brain, and have highlighted the importance of sex-linked genes in this process, either independently, or in combination with, gonadal hormones. Using two rodent models, this thesis investigated the roles of the Y-linked (male-specific) gene Sry and other sex chromosome-linked genes on emotional behaviour. Using an established murine ‘four core genotype’ (FCG) model an attempt was made to dissociate, ‘Sry-dependent effects’ (due to direct effects of Sry brain expression, or to downstream hormonal factors) and effects due to ‘sex chromosome complement’ (i.e. sex-linked genes other than Sry). The mouse work was augmented by the development of a novel rat Sry antisense ‘knockdown’ model permitting investigation of the behavioural effects of direct manipulation of Sry expressed in discrete brain areas.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Mar 2016 23:02
URI:	https://orca.cardiff.ac.uk/id/eprint/36105

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