Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation

Patel, G. K., Morris, E., Rashid, M. R. and Anstey, Alexander Vincent ORCID: https://orcid.org/0000-0002-6345-4144 2000. Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation. British Journal of Dermatology 143 (6) , pp. 1302-1305. 10.1046/j.1365-2133.2000.03906.x

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Abstract

We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this condition arising in a patient in her eighties.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RL Dermatology
Uncontrolled Keywords:	digital necrosis, factor V Leiden, protein C, purpura fulminans
Publisher:	Blackwell Publishing
ISSN:	0007-0963
Last Modified:	21 Oct 2022 09:23
URI:	https://orca.cardiff.ac.uk/id/eprint/36159

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