A review of possible mechanisms of action of the antirheumatic drug, alclofenac

Aylward, Mansel 1975. A review of possible mechanisms of action of the antirheumatic drug, alclofenac. Current Medical Research and Opinion 3 (5) , pp. 249-263. 10.1185/03007997509114775

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Abstract

A number and variety of hypotheses have been proposed to explain the primary mechanism of action of the antirheumatic drugs. A critical review is made of the biochemical and pharmacological parameters which, on current evidence, parallel the clinical activity of the drugs. The numerous chemical mediators of the inflammatory response are discussed, as is the possible role of endogenous anti-inflammatory substances. Particular attention is paid to the plasma protein-bincling effects of antirheumatic drugs and the competitive displacement theory of drug action is examined in the light of recent work on the behaviour of L-tryptophan bincling in vitro and in vivo. It is suggested that antirheumatic drugs can be differentiated by their influence on the acute-phase protein response and their effects on tryptophan bincling. Clinical finclings are reviewed to support the proposal that drugs such as alcofenac, which both inhibit the acute-phase response and exert prolonged influence on the bincling of tryptophan to plasma proteins, reduce inflammatory activity more profoundly than those drugs which produce symptomatic relief alone. They are capable, therefore, of altering the course of the disease. Read More: http://informahealthcare.com/doi/abs/10.1185/03007997509114775

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	anti-inflammatory agents, arthritis, rheumatoid, alclofenac, protein bincling
Publisher:	Informa Healthcare
ISSN:	0300-7995
Last Modified:	04 Jun 2017 04:19
URI:	https://orca.cardiff.ac.uk/id/eprint/36627

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