Fungal infection in the intensive care unit

Flanagan, P. G. and Barnes, Rosemary Ann 1998. Fungal infection in the intensive care unit. Journal of Hospital Infection 38 (3) , pp. 163-177. 10.1016/S0195-6701(98)90271-7

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Abstract

Fungal infection in critically ill patients is an increasingly prevalent problem. Candida spp. cause the majority of these infections in ICU. They occur most commonly in patients with severe underlying illness, multiple courses of antibiotics and intravascular catheters. Clinical diagnosis is difficult due to nonspecific signs and the frequent occurrence of widespread superficial colonization with Candida spp. in ventilated patients. Most patients are diagnosed using inferential evidence of infection, such as persistent pyrexia despite antibiotics, raised serum C-reactive protein and the presence of individual risk factors. Amphotericin B and fluconazole are the most commonly used anti-fungals dependent on the identity of the fungus. Most of these infections are endogenous; however, a proportion may be caused via the hands of healthcare staff or contaminated medical equipment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Uncontrolled Keywords:	intensive care, candida spp., colonization versus infection, amphotericin B, fluconazole, exogenous infection
Publisher:	Elsevier
ISSN:	0195-6701
Last Modified:	04 Jun 2017 04:20
URI:	https://orca.cardiff.ac.uk/id/eprint/37070

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