Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation

Francis, Karen, Lewis, Barbara Mary, Akatsu, Hiroyasu, Monk, Peter N., Cain, Stuart A., Scanlon, Maurice Francis, Morgan, B. Paul, Ham, Jack and Gasque, Philippe 2003. Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation. The FASEB Journal 17 (15) , pp. 2266-8. 10.1096/fj.02-1103fje

Full text not available from this repository.

Abstract

Two-way communication exists between the endocrine and immune systems using molecules such as hormones and cytokines. Here we describe a new pathway by which C3a, a complement-derived cytokine, stimulates anterior pituitary hormone release and activates the hypothalamic-pituitary-adrenal axis, a reflex central to the stress response and to the control of inflammation. We show that C3a receptors are expressed in pituitary hormone secreting and non-hormone secreting (folliculostellate) cells and that both C3a and C3adesArg (a non-inflammatory metabolite) stimulate pituitary cell cultures to release prolactin, growth hormone, and adrenocorticotropin. Serum levels of these hormones, together with adrenal corticosterone, increase dose dependently with recombinant C3a and C3adesArg administration in vivo. Pertussis toxin blocks the response to C3a but not C3adesArg, which indicates the presence of two receptors, only one of which is coupled to G?i-proteins. We propose that the complement innate immune molecules (cytokines) modulate tissue-specific and systemic inflammatory responses through communication with the endocrine pituitary gland. Key words: anaphylatoxin • sepsis • endocrine •

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Anaphylatoxin ; Sepsis ; endocrine ; Hypothalamo-pituitary-adrenal axis
ISSN:	1530-6860
Last Modified:	18 Oct 2017 08:22
URI:	https://orca.cardiff.ac.uk/id/eprint/391

Citation Data

Cited 58 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item