Manufacturing of an array of microneedles in a steel insert for micro-injection moulding using laser milling

Lacan, Franck Andre ORCID: https://orcid.org/0000-0002-3499-5240, Scholz, Steffen Gerhard, Petkov, Petko Vladev ORCID: https://orcid.org/0000-0003-2185-2651 and Dimov, Stefan Simeonov 2011. Manufacturing of an array of microneedles in a steel insert for micro-injection moulding using laser milling. Presented at: 8th International Conference on Multi-Material Micro-Manufacture, Stuttgart, Germany, 8-10 November 2011. Published in: Kück, Heinz, Reinecke, Holger and Dimov, Stefan Simeonov eds. 4M2011-Proceedings of the 8th International Conference on Multi-Material Micro Manufacture. Research Publishing, pp. 336-339. 10.3850/978-981-07-0319-6_249

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Abstract

The use of arrays of hollow micro needles offers the potential of pain free drug delivery through the skin. However, their batch manufacture represents a real challenge. Especially, it is difficult to design and implement reliable and cost effective manufacturing solutions suitable for scale up production of such new drug delivery devices. In this paper the authors report an investigation of possible manufacturing process chains for producing steel mould inserts for serial replication of microneedles’ patches employing injection moulding. The focus is on manufacturing solutions that utilise nano-second and pico-second laser milling for machining the necessary replication inserts. The process optimisation issues associated with their manufacture are discussed, and the processing windows that were determined are described. To validate the proposed tool-making process chains some moulding inserts were successfully machined using both laser milling technologies. Finally the limitations and uncertainties of these tool making process chains are discussed.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Engineering
Subjects:	T Technology > TJ Mechanical engineering and machinery
Uncontrolled Keywords:	Hollow microneedles ; Laser milling ; Micro injection moulding
Publisher:	Research Publishing
ISBN:	9789810703202
Last Modified:	21 Oct 2022 10:08
URI:	https://orca.cardiff.ac.uk/id/eprint/39155

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