Doppler ultrasound flowmetry predicts 15 year outcome in patients with skin melanoma

Srivastava, Anurag, Woodcock, John Patrick, Mansel, Robert Edward ORCID: https://orcid.org/0000-0002-8051-0726, Webster, David J. T., Laidler, Peter, Hughes, Leslie E. and Dwivedi, Alok 2012. Doppler ultrasound flowmetry predicts 15 year outcome in patients with skin melanoma. Indian Journal of Surgery 74 (4) , pp. 278-283. 10.1007/s12262-011-0398-z

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Abstract

This prospective cohort study was conducted to find the role of tumor neovascularization in skin melanoma measured by preoperative Doppler ultrasound flowmetry in determining the 15-year outcome. Setting: Department of Surgery, University of Wales College of Medicine, Cardiff, UK. Seventy-one primary melanomas in 67 patients were studied with a 10 MHz Doppler ultrasound flowmeter. The flow signals were recorded on an audiotape. The peak systolic frequency, mean systolic frequency, and minimum diastolic frequency were measured on a spectrum analyzer. The follow-up (median 144 months) information is complete till December 2005 on 63 patients. Blood flow signals were detected in 41 lesions; these were labeled Doppler flow positive. No flow was detected in 22 lesions, labeled Doppler flow negative. Among the Doppler flow positive group, 39% patients have died with metastatic melanoma, whereas none of the patients with a Doppler-negative lesion have died or developed any recurrence. Higher peak systolic frequency (above 2,500 MHz.) was associated with a hazard ratio for death due to melanoma of (HAZARD RATE = 5.99). Higher risk of death, locoregional, and systemic recurrences were associated with higher peak systolic frequency. Doppler flowmetry performed preoperatively is a noninvasive, quick, and simple method to assess tumor blood flow which may help in predicting long-term survival and planning neoadjuvant therapies aimed at inhibiting angiogenesis or targeting tumor vasculature.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Tumor blood flow – Neovascularization – Malignant melanoma – Recurrence – Doppler ultrasound flowmetry – Cohort study – Survival
Publisher:	Springer
ISSN:	0972-2068
Last Modified:	21 Oct 2022 10:24
URI:	https://orca.cardiff.ac.uk/id/eprint/40071

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