Association of postpartum thyroid dysfunction with antepartum hormonal and immunological changes

Kokandi, A. A., Parkes, Arthur Burnham, Premawardhana, Lakdassa D. K. E., John, R. and Lazarus, John Henry 2003. Association of postpartum thyroid dysfunction with antepartum hormonal and immunological changes. Journal of Clinical Endocrinology & Metabolism 88 (3) , pp. 1126-32. 10.1210/jc.2002-021219

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Abstract

Postpartum thyroid dysfunction (PPTD) develops during the first 9 months in up to 50% of women who have thyroid peroxidase antibodies (anti-TPOAb +ve). Humoral immunity in PPTD has been well documented, but the cellular immunological events accompanying the Th2 to Th1 state postpartum are less clear. Peripheral blood lymphocyte cytokine secretion was examined in 48 TPOAb +ve and 33 TPOAb -ve women at 36 wk gestation and at 6, 12, and 24 wk postpartum. Eighteen women with PPTD had significantly greater secretion of interferon and IL-4 than euthyroid women at 36 wk gestation with no significant differences in cytokine secretion at other time points. Also, at 36 wk gestation, the median plasma cortisol concentration in the PPTD group was significantly lower than the euthyroid group (442 nmol/liter vs. 567 nmol/liter, P < 0.02). There were no differences between the groups in levels of prolactin, progesterone, or estradiol. These data suggest that there may be less immunological suppression at 36 wk in TPOAb +ve women destined to develop PPTD possibly because of lower levels of cortisol. Thus, the immunological determinants of PPTD may in part occur antenatally, although the mechanism(s) for this is still unclear.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	IFN ; Interferon ; PPT ; Postpartum thyroiditis ; PPTD ; Postpartum thyroid dysfunction ; PPTE ; Euthyroid postpartum ; TPOAb ; Thyroid peroxidase autoantibodies ; TPOAb +ve ; Antithyroid peroxidase antibody positive.
ISSN:	0021-972X
Last Modified:	30 Jun 2017 01:31
URI:	https://orca.cardiff.ac.uk/id/eprint/405

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