Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder

Fisher, Helen L., Cohen-Woods, Sarah, Hosang, Georgina M., Korszun, Ania, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Craig, Ian W., Farmer, Anne E., McGuffin, Peter and Uher, Rudolf 2013. Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder. Journal of Affective Disorders 145 (1) , pp. 136-141. 10.1016/j.jad.2012.05.032

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Abstract

Background There is inconsistent evidence of interaction between stressful events and a serotonintransporter promoter polymorphism (5-HTTLPR) in depression. Recent studies have indicated that the moderating effect of 5-HTTLPR may be strongest when adverse experiences have occurred in childhood and the depressive symptoms persist over time. However, it is unknown whether this gene–environment interaction is present for recurrentdepressivedisorder and different forms of maltreatment. Therefore, patients with recurrent clinically diagnosed depression and controls screened for the absence of depression were utilised to examine the moderating effect of 5-HTTLPR on associations between specificforms of childhood adversity and recurrent depression. Method A sample of 227 recurrent unipolar depression cases and 228 never psychiatrically ill controls completed the Childhood Trauma Questionnaire to assess exposure to sexual, physical and emotional abuse, physical and emotional neglect in childhood. DNA extracted from blood or cheek swabs was genotyped for the short (s) and long (l) alleles of 5-HTTLPR. Results All forms of childhoodmaltreatment were reported as more severe by cases than controls. There was no direct association between 5-HTTLPR and depression. Significant interactions with additive and recessive 5-HTTLPR genetic models were found for overall severity of maltreatment, sexual abuse and to a lesser degree for physical neglect, but not other maltreatment types. Limitations The cross-sectional design limits causal inference. Retrospective report of childhood adversity may have reduced the accuracy of the findings. Conclusions This study provides support for the role of interplay between 5-HTTLPR and a specific early environmental risk in recurrentdepressivedisorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	childhood maltreatment, unipolar depression, recurrent, serotonin transporter gene, gene–environment interaction, 5-HTTLPR
Publisher:	Elsevier
ISSN:	0165-0327
Last Modified:	21 Oct 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/41052

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