Balasingham, Rebeca, Williams, Catrin Ffion  ORCID: https://orcid.org/0000-0001-8619-2581, Mottram, Huw James, Coogan, Michael Peter and Pope, Simon J. A. ORCID: https://orcid.org/0000-0001-9110-9711
2012.
Gold(I) complexes derived from alkynyloxy-substituted anthraquinones: Syntheses, luminescence, preliminary cytotoxicity, and cell imaging studies.
Organometallics
31
(16)
, pp. 5835-5843.
10.1021/om300475y
|
Abstract
A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Subjects: | Q Science > QD Chemistry |
| Publisher: | American Chemical Society |
| ISSN: | 0276-7333 |
| Last Modified: | 09 Nov 2022 07:56 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/41617 |
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