Clinical trials of neural transplantation in Huntington's disease

Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Bachoud-Lévi, Anne-Catherine 2012. Clinical trials of neural transplantation in Huntington's disease. Progress in Brain Research, Vol. 200. Elsevier, pp. 345-371. (10.1016/B978-0-444-59575-1.00016-8)

Full text not available from this repository.

Abstract

Clinical neural transplantation in Huntington's disease has moved forward as a series of small studies, which have provided some preliminary proof of principle that neural transplantation can provide benefit. However, to date, such benefits have not been robust, and there are a number of important issues that need to be addressed. These include defining the optimum donor tissue conditions and host characteristics in order to produce reliable benefit in transplant recipients, and whether, and for how long, immunosuppression is needed. Further clinical studies will be required to address these, and other issues, in order to better understand the processes leading to a properly functioning neural graft. Such studies will pave the way for future clinical trials of renewable donor sources, in particular, stem cell-derived neuronal progenitor grafts.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	clinical trials; Huntington's disease; human tissue; primary fetal tissue; transplantation
Additional Information:	Functional Neural Transplantation III — Primary and Stem Cell Therapies for Brain Repair, Part I
Publisher:	Elsevier
ISSN:	0079-6123
Last Modified:	21 Oct 2022 10:55
URI:	https://orca.cardiff.ac.uk/id/eprint/41737

Citation Data

Cited 29 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item