Increased central arterial stiffness in hypothyroidism

Obuobie, Kofi, Smith, J., Evans, L. M., John, R., Davies, J. S. and Lazarus, John Henry 2002. Increased central arterial stiffness in hypothyroidism. Journal of Clinical Endocrinology & Metabolism 87 (10) , pp. 4662-6. 10.1210/jc.2002-020493

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Abstract

Hypothyroidism is associated with cardiovascular dysfunction. It is increasingly apparent that stiffening of central arteries may lead to increased afterload and cardiac dysfunction. We noninvasively studied the peripheral and central pressure waveforms in 12 untreated hypothyroid patients as well as in 12 age-, sex-, and body mass index-matched controls using the technique of pulse wave analysis from recordings at the radial artery. Indexes of arterial stiffness, augmentation index (AI) and augmentation of central arterial pressure (AG), were derived as well as time of travel of the reflected wave (TR), a direct estimate of aortic pulse wave velocity. At baseline, there were no significant differences between the 2 groups in brachial and aortic blood pressures. Hypothyroid patients had significantly higher AI than controls (mean

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Hypothyroidism
ISSN:	0021-972X
Last Modified:	30 Jun 2017 01:31
URI:	https://orca.cardiff.ac.uk/id/eprint/420

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