Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans

Torrents-Rodas, David, Fullana, Miquel A., Arias, Bárbara, Bonillo, Albert, Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891, Andión, Oscar, Mitjans, Marina, Fañanás, Lourdes and Torrubia, Rafael 2012. Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans. Psychophysiology 49 (5) , pp. 713-719. 10.1111/j.1469-8986.2011.01352.x

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Abstract

Few studies have investigated the role of the BDNF-val66met polymorphism in fear conditioning in humans, and previous results have been inconsistent. In the present study, we examined whether the BDNF-val66met was associated with differences in the acquisition and generalization of fear during a differential conditioning paradigm in a large sample of participants (N = 141). Using three different indexes of fear learning (fear-potentiated startle, skin conductance response, and online risk ratings) no effects of the BDNF-val66met were found either on the acquisition or the generalization of conditioned fear. Taken together with previous data, our study suggests that the BDNF-val66met polymorphism has no effect on the acquisition or generalization of fear.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	genetics, conditioning, emotion, individual differences
Publisher:	Blackwell Publishing
ISSN:	0048-5772
Last Modified:	24 Oct 2022 09:48
URI:	https://orca.cardiff.ac.uk/id/eprint/42166

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