Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya

El Salabi, Allaaeddin, Borra, P. S., Toleman, Mark Alexander Howard ORCID: https://orcid.org/0000-0002-9497-0512, Samuelsen, O. and Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096 2012. Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy 56 (5) , pp. 2241-2245. 10.1128/AAC.05640-11

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Abstract

An Achromobacter xylosoxidans strain from the Tripoli central hospital produced a unique metallo-β-lactamase, designated TMB-1, which is related to DIM-1 (62%) and GIM-1 (51%). blaTMB-1 was embedded in a class 1 integron and located on the chromosome. The TMB-1 β-lactamase has lower kcat values than both DIM-1 and GIM-1 with cephalosporins and carbapenems. The Km values were more similar to those of GIM-1 than those of DIM-1, with the overall kcat/Km values being lower than those for GIM-1 and DIM-1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0066-4804/ (accessed 24/02/2014)
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Date of First Compliant Deposit:	30 March 2016
Last Modified:	08 May 2023 12:53
URI:	https://orca.cardiff.ac.uk/id/eprint/42324

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