Improving the detection of grey matter lesions in MS using MRI: A comparison of double inversion recovery and phase sensitive inversion recovery [Abstract]

Sethi, Varun, Yousry, Tarek, Muhlert, Nils ORCID: https://orcid.org/0000-0002-6414-5589, Ron, Maria, Golay, Xavier, Wheeler-Kingshott, Claudia, Miller, David and Chard, Declan 2012. Improving the detection of grey matter lesions in MS using MRI: A comparison of double inversion recovery and phase sensitive inversion recovery [Abstract]. Neurology 78 , S51.001. 10.1212/WNL.78.1_MeetingAbstracts

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Abstract

Objective: Study the extent & distribution of cortical GM lesions in MS patients & healthy controls using Phase Sensitive Inversion Recovery (PSIR). Background The presence, distribution & evolution of white matter lesions seen on MRI helps diagnose MS. Extensive cortical gray matter(GM) involvement is seen histo-pathologically, but not using conventional MRI. Double inversion recovery(DIR) increased detection of GM lesions, but falls short of histopathological observations. PSIR has recently been investigated to help improve GM lesion detection. Design/Methods: 30 controls(mean age±SD 37.8±11.8 years) & 57 patients(46±11 years) were studied{30 relapsing remitting (RR)MS, 12 primary (PP) & 15 secondary progressive (SP)MS)}. FLAIR, PD/T2, PSIR & DIR images were obtained using a 3T Philips Achieva System. Lesions were marked on PSIR & DIR independently(FLAIR &PD/T2 as reference). GM lesions(involved GM at any point) were marked. They were sub-classified as pure GM(involve only the GM) or mixed GM-white matter(WM) lesions. On PSIR, we also identified juxtacortical WM lesions(touching, not involving cortical GM), separate from mixed GM-WM lesions. Results: On DIR, number of pure GM lesions was (mean±SD) 4.3±5.1 in RR, 2.0±1.8 in PP, 8.5±4.8 in SPMS, & mixed GM-WM lesions was 9.5±11.0 in RR, 4.8±3.4 in PP and 21.4±10.3 in SPMS. On PSIR, mean number of pure GM lesions was 11.4±10.5 in RR, 6.6±4.5 in PP, 28.3±17.0 in SPMS, & mixed GM-WM lesions 15.4±15.8 in RR, 10±6.7 in PP & 39.3±21.0 in SPMS. When juxtacortical lesions were added to the number of GM-WM lesions, the counts were 18.7±17.9 in RR, 12.5±7.9 in PP & 50.2±27.7 in SPMS. On PSIR, pure GM lesion was seen in 1/30 healthy controls and in 49/57 patients. Conclusions: PSIR identifies 2-3x more GM lesions than DIR. Apparently pure GM were seen in 80% of patients, but <5% controls, suggesting that PSIR may have a role in the diagnosis of MS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Academy of Neurology
ISSN:	0028-3878
Last Modified:	24 Oct 2022 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/42923

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