Novel multi-metallic luminescent complexes towards dual-functional cellular and therapeutic applications

Balasingham, Rebeca Glory 2012. Novel multi-metallic luminescent complexes towards dual-functional cellular and therapeutic applications. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

A series of novel multi-metallic luminescent Au(I) and Re(I) complexes have been synthesised targeting functionality as cellular imaging and/or therapeutic agents. Both the ligands and their complexes have been characterised by a variety of spectroscopic and spectrometric techniques. Several complexes were also characterised by X-ray crystal diffraction and/or elemental analysis. In both chapters two and three the modulation of the luminescent properties of a series of mono- and di-metallic [Re(CO)3(N^N)L]+ type complexes bearing functionalised alkyl chains by hydrophobically driven, intra- and intermolecular conformational changes is reported. Additionally, the first application of di-metallic Re(I) complexes in cellular imaging is reported with specific localisation in the nucleoli or ER and Golgi apparatus. In both chapters four and five the synthesis of novel mono- and di-metallic Au(I) complexes is reported. Several complexes demonstrated cytotoxicity as well as compartemental localisation in cellular imaging demonstrating their potential as dual-functional cellular imaging and/or therapeutic agents. As an extension to the work discussed in Chapters two to five, the synthesis of novel multi-metallic luminescent complexes is reported in Chapter six. For the tri-hetero-metallic complex incorporating Au(I) and Re(I) units, cytotoxicity towards four cancer cell lines and non-specific localization throughout the entire cell is described.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Date of First Compliant Deposit:	30 March 2016
Last Modified:	04 Jun 2017 04:41
URI:	https://orca.cardiff.ac.uk/id/eprint/43088

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