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Ultraviolet transmission through the human corneal stroma

Doutch, James J., Quantock, Andrew James ORCID:, Joyce, Nancy C. and Meek, Keith Michael Andrew ORCID: 2012. Ultraviolet transmission through the human corneal stroma. Biophysical Journal 102 (6) , pp. 1258-1264. 10.1016/j.bpj.2012.02.023

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This article investigates in vitro light transmission through the human cornea in the ultraviolet (UV) portion of the electromagnetic spectrum as a function of position across the cornea from center to periphery. Spectrophotometry was used to measure UV transmission in the wavelength range 310–400 nm, from the central cornea to its periphery. UV transmission decreases away from the center, and this is attributed to scattering and absorbance. Corneal endothelial cells, which line the back of the cornea and are more numerous in the periphery, therefore receive a lower dose of UV than do those in the central cornea. This is consistent with the recent observation that endothelial cells in the corneal periphery exhibit less nuclear oxidative DNA damage than those in the central cornea.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: Biophysical Society
Funders: MRC
Last Modified: 24 Oct 2022 10:22

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