Rose-bengal-photosensitized formation of hydrogen peroxide and hydroxyl radicals

Różanowska,, Malgorzata Barbara ORCID: https://orcid.org/0000-0003-2913-8954, Ciszewska, Joanna, Korytowski, Witold and Sarna, Tadeusz 1995. Rose-bengal-photosensitized formation of hydrogen peroxide and hydroxyl radicals. Journal of Photochemistry and Photobiology B: Biology 29 (1) , pp. 71-77.

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Abstract

Electron transfer reactions between several electron donors, including common antioxidants such as ascorbate, reduced glutathione and trolox, and the lowest triplet excited state of Rose Bengal (RB) lead to the formation of free radicals that are capable of reducing molecular oxygen and redox-active metal ions. We studied RB-photosensitized redox reactions and the formation of hydroxyl radicals by direct electron spin resonance (ESR) and ESR-spin-trapping techniques respectively. Our data indicate that the free-radical pathway of RB-photosensitized oxidation reactions (PORs) can, under certain conditions, compete efficiently with the singlet oxygen route. The protective action of antioxidants in PORs may be compromised by their ability to serve as primary electron donors in photosensitized electron transfer. Owing to its metal ion sequestering ability and free-radical scavenging efficiency, melanin exhibits powerful antioxidant action that may reduce the damaging efficacy of photodynamic phenomena in pigmented cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords:	Rose Bengal ; Photosensitization ; Electron transfer ; Oxygen reactive species ; Free radicals ; Antioxidants; Melanin ; Electron spin resonance
Publisher:	Elsevier
ISSN:	1011-1344
Last Modified:	24 Oct 2022 10:22
URI:	https://orca.cardiff.ac.uk/id/eprint/44105

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