Protein antigens of Staphylococcus epidermidis grown under iron-restricted conditions in human peritoneal dialysate

Williams, P., Denyer, Stephen Paul and Finch, R. G. 1988. Protein antigens of Staphylococcus epidermidis grown under iron-restricted conditions in human peritoneal dialysate. FEMS Microbiology Letters 50 (1) , pp. 29-33. 10.1111/j.1574-6968.1988.tb02906.x

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Abstract

Comparison of the whole cell protein profiles of Staphylococcus epidermidis grown in pooled human peritoneal dialysate (HPD) with those of cells grown in nutrient broth (NB) revealed proteins of 27, 39, 45, 54 and 98 kDa which were absent or poorly expressed in NB-grown cells. IgG, but not transferrin, was detected bound to the surface of bacteria grown in HPD. Immunoblotting experiments revealed that IgG antibodies present in pooled HPD recognised staphylococcal protein antigens of 16, 27, 35, 39, 45, 54 and 98 kDa. The 16-, 35- and 39-kDa antigens which were associated with the cytoplasmic membrane were repressed following growth in NB or in HPD supplemented with excess iron.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Staphylococcus epidermidis; Peritonitis; Protein antigens; Iron; Transferrin; Dialysis; Continuous ambulatory peritoneal
Publisher:	Wiley-Blackwell
ISSN:	0378-1097
Last Modified:	19 Mar 2016 23:14
URI:	https://orca.cardiff.ac.uk/id/eprint/44230

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