'In vivo' bioluminescence: A cellular reporter for research and industry [Abstract]

Jassim, S. A. A, Ellison, A., Denyer, Stephen Paul and Stewart, G. S. A. B. 1990. 'In vivo' bioluminescence: A cellular reporter for research and industry [Abstract]. Journal of Bioluminescence and Chemiluminescence 5 (2) , pp. 115-122. 10.1002/bio.1170050207

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Abstract

The detection of specific bacterial pathogens, indicator microorganisms and antimicrobial substances, and the recovery of microorganisms from sub-lethal injury, are all aspects of importance to industry which are currently being targeted using in vivo bioluminescence. In all instances, a key requirement for the application of bioluminescence is the establishment of a strict correlation between in vivo bioluminescence and cell viability, as determined by colony counting on agar plates. Comparative studies for biocides (phenol, chlorhexidine diacetate, phenol thioether), for a virucide (hypochlorite) and for cellular recovery of S. typhimurium from sub-lethal injury, all indicate that such a correlation is valid. Furthermore, real-time measurements of in vivo bioluminescence reveal a major population of bacterial cells that retain functional intracellular biochemistry, but are defective in their ability to replicate post of freeze injury.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	in vivo bioluminescence; biocides; virucides; sub-lethal injury
Publisher:	Wiley-Blackwell
Last Modified:	19 Mar 2016 23:14
URI:	https://orca.cardiff.ac.uk/id/eprint/44236

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