Decontamination methods for cytotoxic drugs. 1. Use of a bioluminescent technique to monitor the inactivation of methotrexate with chlorine–based agents

Wren, A. E., Melia, C. D., Garner, S. T. and Denyer, Stephen Paul 1993. Decontamination methods for cytotoxic drugs. 1. Use of a bioluminescent technique to monitor the inactivation of methotrexate with chlorine–based agents. Journal of Clinical Pharmacy and Therapeutics 18 (2) , pp. 133-137. 10.1111/j.1365-2710.1993.tb00579.x

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Abstract

A new microbial bioluminescence assay has been used to monitor the loss of mutagenicity on inactivation of methotrexate by active chlorine–based agents. The drug was degraded to products that were non–active in this mutagen detection system, in agreement with previously described work. Presept granules appear to be a suitable alternative to sodium hypochlorite for inactivating solutions and surface spills of methotrexate. The bioluminescence assay appears to have potential for monitoring clean–up and decontamination procedures in areas where cytotoxic agents are used.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Wiley-Blackwell
ISSN:	1365-2710
Last Modified:	19 Mar 2016 23:14
URI:	https://orca.cardiff.ac.uk/id/eprint/44253

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