The psychological side effects of acebutolol and atenolol

Lewis, M. J., Jones, Dylan Marc ORCID: https://orcid.org/0000-0001-8783-5542, Dart, A. M. and Henderson, A. H. 1984. The psychological side effects of acebutolol and atenolol. British Journal Of Clinical Pharmacology 17 (3) , pp. 364-366. 10.1111/j.1365-2125.1984.tb02356.x

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Abstract

We have measured the psychological effects of acebutolol and atenolol in sixteen patients with essential hypertension. The drugs were administered in a randomized, placebo-controlled, double-blind manner, in single daily doses of 100 mg atenolol, 400 mg acebutolol or placebo for periods of 6 weeks, each drug period being separated by a placebo period. At each 2 weekly clinic visit, a questionnaire designed for assessment of state anxiety and state arousal was administered for self- completion. Arousal was significantly reduced by atenolol over the whole 6 weeks of administration. It was not affected by acebutolol. Anxiety was significantly reduced by acebutolol but only at the first of the three 2 weekly assessments on treatment. It was not affected by atenolol. Differences in the psychological effects of these two beta- adrenoceptor blockers are discussed in terms of their lipid solubility and haemodynamic effects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RM Therapeutics. Pharmacology
Publisher:	Blackwell Publishing
ISSN:	0306-5251
Last Modified:	24 Oct 2022 10:25
URI:	https://orca.cardiff.ac.uk/id/eprint/44337

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