Scleral anisotropy and its effects on the mechanical response of the optic nerve head

Coudrillier, Baptiste, Boote, Craig ORCID: https://orcid.org/0000-0003-0348-6547, Quigley, Harry A. and Nguyen, Thao D. 2013. Scleral anisotropy and its effects on the mechanical response of the optic nerve head. Biomechanics and Modeling in Mechanobiology 12 (5) , pp. 941-963. 10.1007/s10237-012-0455-y

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Abstract

This paper presents a computational modeling study of the effects of the collagen fiber structure on the mechanical response of the sclera and the adjacent optic nerve head (ONH). A specimen-specific inverse finite element method was developed to determine the material properties of two human sclera subjected to full-field inflation experiments. A distributed fiber model was applied to describe the anisotropic elastic behavior of the sclera. The model directly incorporated wide-angle X-ray scattering measurements of the anisotropic collagen structure. The converged solution of the inverse method was used in micromechanical studies of the mechanical anisotropy of the sclera at different scales. The effects of the scleral collagen fiber structure on the ONH deformation were evaluated by progressively filtering out local anisotropic features. It was found that the majority of the midposterior sclera could be described as isotropic without significantly affecting the mechanical response of the tissues of the ONH. In contrast, removing local anisotropic features in the peripapillary sclera produced significant changes in scleral canal expansion and lamina cribrosa deformation. Local variations in the collagen structure of the peripapillary sclera significantly influenced the mechanical response of the ONH.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Uncontrolled Keywords:	Sclera; Optic nerve head; Inverse finite element method; Wide-angle X-ray scattering; Inflation experiment
Publisher:	Springer
ISSN:	1617-7959
Last Modified:	24 Oct 2022 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/44482

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