A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk

Lewis, Sarah J., Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Gunnell, David and Smith, George Davey 2005. A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1) , pp. 2-4. 10.1002/ajmg.b.30170

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Abstract

Epigenetic mechanisms such as methylation of DNA, could lead to abnormal neurodevelopment and may be important in the etiology of schizophrenia. Maternal dietary folate intake may play a role in determining methylation levels. The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18–1.86). This supports the hypothesis that folate status is a determinant of schizophrenia risk. Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important. © 2005 Wiley-Liss, Inc.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	MTHFR, schizophrenia, folate, polymorphism
Publisher:	Wiley-Blackwell
ISSN:	1552-4841
Related URLs:	Publisher
Last Modified:	24 Oct 2022 10:31
URI:	https://orca.cardiff.ac.uk/id/eprint/44686

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