Dental tissue repair: Novel models for tissue regeneration strategies

Sloan, Alastair James ORCID: https://orcid.org/0000-0002-1791-0903 and Lynch, Christopher Daniel 2012. Dental tissue repair: Novel models for tissue regeneration strategies. The Open Dentistry Journal 6 (1) , pp. 214-219. 10.2174/1874210601206010214

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Abstract

Studies have shown that dentin matrices contain reservoirs of bioactive molecules capable of directing tissue repair. Elucidating the release mechanisms of such endogenous growth factors will enhance our understanding of dentinpulp regeneration and support the development of novel treatment modalities to enhance dentin repair following trauma and disease. Current clinical practice using new materials which are perceived to maintain pulpal viability require biological evidence to assess their therapeutic benefit and there is a need for better effective methods of assessing therapeutic approaches to improving dentin regeneration at the cellular and tissue level. Experimental modelling of dentin regeneration is hampered by the lack of suitable models. In vivo and in vitro studies have yielded considerable information on the processes taking place, but are limited, due to the cost, ethics and lack of cell/matrix interactions. Novel organotypic models, whereby cells and tissues are cultured in situ may provide a more suitable model system to facilitate dental tissue engineering and regeneration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	R Medicine > RK Dentistry
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/pub/1419/ (accessed 25/02/2014)
Publisher:	Bentham Open
ISSN:	1874-2106
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 00:19
URI:	https://orca.cardiff.ac.uk/id/eprint/44946

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