An alternative strategy to the Pictet-Spengler method for tetrahydroisoquinoline synthesis: a feasibility study

Henderson, Laura, Knight, David William and Williams, Andrew C. 2012. An alternative strategy to the Pictet-Spengler method for tetrahydroisoquinoline synthesis: a feasibility study. Tetrahedron Letters 53 (35) , pp. 4657-4660. 10.1016/j.tetlet.2012.06.091

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Abstract

Acid-catalysed cyclisations of the 2-aminoethyl styrene derivatives 9 give good to excellent yields of the corresponding tetrahydroisoquinolines 7 by an intramolecular hydroamination reaction, which represents an alternative and potentially more flexible strategy to the classical Pictet–Spengler method for the syntheses of such heterocycles.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Pictet–Spengler; Alternative; Hydroamination; Acid-catalysed; Cyclisation
Publisher:	Elsevier
ISSN:	0040-4039
Last Modified:	06 May 2023 01:29
URI:	https://orca.cardiff.ac.uk/id/eprint/45501

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