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What can progeroid syndromes tell us about human aging?

Kipling, David Glyn, Davis, Terence, Ostler, Elizabeth L. and Faragher, Richard G. A. 2004. What can progeroid syndromes tell us about human aging? Science 305 (5689) , pp. 1426-1431. 10.1126/science.1102587

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Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 04 Jun 2017 04:57

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