On the regiochemistry of Mitsunobu alkylations of hydrazine derivatives

Dunford, Damian G., Chaudhry, Faryal, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897, Knight, David William and Wheeler, Robert C. 2012. On the regiochemistry of Mitsunobu alkylations of hydrazine derivatives. Tetrahedron Letters 53 (51) , pp. 7006-7009. 10.1016/j.tetlet.2012.10.084

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Abstract

That differentially protected hydrazines of the type TsNHNHCOR3 undergo regiospecific Mitsunobu reactions with a variety of alcohols, R1R2CHOH in a generalised manner, to give good to excellent yields of the mono-adducts Ts(R1R2CH)NNHCOR3, has been proven by X-ray crystallographic analysis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Publisher:	Elsevier
ISSN:	0040-4039
Last Modified:	06 May 2023 01:29
URI:	https://orca.cardiff.ac.uk/id/eprint/47162

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